Do not use any Seachem or other medications while running either an ozonizer or UV sterilizer on a system. This is a safe rule to stick to with any medications. Ozone and UV light destroy most medications but will, in some cases, convert the medications to more toxic substances: e.g. chelated coppers are converted to standard copper sulfate the chelating agent is destroyed producing a more toxic form of copper

Do not use any Seachem or other medications while running any form of chemical filtration: e.g., activated carbon, most resins, protein skimmer. These modes of chemical filtration will usually remove most forms of medications quite rapidly. The exception to this rule is Seachem's Purigen™ which focuses on organic removal specifically and will not remove many forms of medication from solution.

Do not combine any Seachem or other medications without knowing that the specific combination is not toxic. Combinations of medications, as with humans, can often be toxic in the aquarium: e.g., combining aldehyde medications with copper medications can increase toxicity of the copper tremendously. The safest bet is not to combine medications at all.

Do not use any Seachem or other medications outside of intended use of the product or its instructions: e.g., use of saltwater medication in freshwater. This voids any repsonsibility that any manufacturer may have regaring the product and it is assumed that the product is being used at one's own risk.

Do not dose any aquarium for the dimensional volume: e.g., a fully decorated 75 gallon aquarium may have only 60 gallons of actual water volume. Failure to dose according to the actual water volume may lead to potentially toxic overdoses of many medications.

Do not dose invertabrate aquariums with medications unless you are certain all of the invertabrates will not react negatively. There is no manner of testing medications on all of the different types of invertabrates. Dosing a system with invertabrates is usually quite risky.

Do not treat a system without being aware of potential risks the medication may pose to individual species; e.g., "scaleless" species, delicate species, etc.